BDBM642358 US20230406840, Example 32

SMILES CC1(CC1)c1ccc2c(ccnc2c1)C(=O)NCC(=O)N1[C@H]2C[C@H]2C[C@H]1C#N

InChI Key InChIKey=ADLFNXLVJAVYNM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 642358   

TargetProlyl endopeptidase FAP(Human)
Astrazeneca

US Patent
LigandPNGBDBM642358(US20230406840, Example 32)
Affinity DataIC50: 2nMAssay Description:Table 1A: Compounds were tested in a biochemical inhibition assay using hFAP enzyme at 0.24 nM FAC (Proteros, 38-760 (PR-0071)) and the substrate Ala...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
US Patent

TargetPresequence protease, mitochondrial(Human)
Astrazeneca

US Patent
LigandPNGBDBM642358(US20230406840, Example 32)
Affinity DataIC50: 5.00E+4nMAssay Description:Table 3: Compounds were tested in a biochemical inhibition assay using Prolyl endopeptidase, Prolyl Oligopeptidase (hPREP) enzyme at 0.6 nM FAC (R&D ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
US Patent