BDBM642364 US20230406840, Example 38

SMILES FC1(F)CCC(CC1)Oc1ccc2nccc(C(=O)NCC(=O)N3[C@H]4C[C@H]4C[C@H]3C#N)c2c1

InChI Key InChIKey=NCGRKPMLHWERDQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 642364   

TargetProlyl endopeptidase FAP(Human)
Astrazeneca

US Patent
LigandPNGBDBM642364(US20230406840, Example 38)
Affinity DataIC50: 1.30nMAssay Description:Table 1A: Compounds were tested in a biochemical inhibition assay using hFAP enzyme at 0.24 nM FAC (Proteros, 38-760 (PR-0071)) and the substrate Ala...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
US Patent

TargetPresequence protease, mitochondrial(Human)
Astrazeneca

US Patent
LigandPNGBDBM642364(US20230406840, Example 38)
Affinity DataIC50: 5.00E+4nMAssay Description:Table 3: Compounds were tested in a biochemical inhibition assay using Prolyl endopeptidase, Prolyl Oligopeptidase (hPREP) enzyme at 0.6 nM FAC (R&D ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
US Patent