BDBM642774 4-(difluoromethyl)-N-(1-(ethylsulfonyl)piperidin-4-yl)-1-isopropyl-1H- [1,2,3]triazolo[4,5-h]quinazolin-8-amine::US20230416271, Compound II.28

SMILES CCS(=O)(=O)N1CCC(CC1)Nc1ncc2cc(C(F)F)c3nnn(C(C)C)c3c2n1

InChI Key InChIKey=WZQSDNJOORXCQA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 642774   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology

US Patent
LigandPNGBDBM642774(4-(difluoromethyl)-N-(1-(ethylsulfonyl)piperidin-4...)
Affinity DataIC50:  0.200nMAssay Description:Assay of Kinase Activity The inhibitory effect of compounds against the kinase CDK4/cyclin D3 was detected by Caliper Mobility Shift Assay method. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology

US Patent
LigandPNGBDBM642774(4-(difluoromethyl)-N-(1-(ethylsulfonyl)piperidin-4...)
Affinity DataIC50:  7nMAssay Description:Assay of Kinase Activity The inhibitory effect of compounds against the kinase CDK4/cyclin D3 was detected by Caliper Mobility Shift Assay method. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology

US Patent
LigandPNGBDBM642774(4-(difluoromethyl)-N-(1-(ethylsulfonyl)piperidin-4...)
Affinity DataIC50:  3nMAssay Description:Assay of Kinase Activity The inhibitory effect of compounds against the kinase CDK4/cyclin D3 was detected by Caliper Mobility Shift Assay method. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent