BDBM642886 (2S,4aS,6aS,6bR,8aR,9S,10R,12aS,12bR,14bR)-10-(acetyloxy)-2,4a,6a,6b,9,10,12a-heptamethyl-13-oxo-9-({[2-oxo-5-(propan-2-yl)-2H-1,3-dioxol-4-yl]methoxy}carbonyl)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 702-1::US20240209019, Compound 702-1

SMILES CC(C)c1oc(=O)oc1COC(=O)[C@@]1(C)[C@@H]2CC[C@]3(C)[C@H](C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O)[C@@]2(C)CC[C@@]1(C)OC(C)=O

InChI Key InChIKey=MTLRBHUTAAKIPX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 642886   

Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Ardelyx

US Patent
LigandPNGBDBM642886((2S,4aS,6aS,6bR,8aR,9S,10R,12aS,12bR,14bR)-10-(ace...)
Affinity DataIC50: 398nMAssay Description:Compounds were diluted in DMSO and serial dilutions prepared by titrating in DMSO. Compounds were then diluted into DMEM/F12. Transwell plates contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Ardelyx

US Patent
LigandPNGBDBM642886((2S,4aS,6aS,6bR,8aR,9S,10R,12aS,12bR,14bR)-10-(ace...)
Affinity DataIC50: 398nMAssay Description:Human descending colon epithelial stem cells were cultured as 3D organoids in accordance with Sato et al Gastroenterology. 2011 November; 141(5): 176...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2024
Entry Details
US Patent