BDBM643759 Preparation of 4-amino-5-(5-(4-methylpiperazin-1-yl-2,2,6,6-d4)-1H-benzo[d]imidazol-2-yl)thieno[2,3-b]pyridin-6(7H)-one ::US20240002394, Example 4

SMILES [2H]C1([2H])CN(C)CC([2H])([2H])N1c5ccc4[nH]c(c3c(N)c2ccsc2[nH]c3=O)nc4c5

InChI Key InChIKey=WKFZMTSRRQSGEY-OSEHSPPNSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 643759   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM643759(Preparation of 4-amino-5-(5-(4-methylpiperazin-1-y...)
Affinity DataIC50: 9.20nMAssay Description:The kinase buffer (Enzymatic buffer 5×) was diluted to 1×, and 10 mM MgCl2, 1 mM DTT, and 0.005% Tween 20 were added. The 100 ng/μL HPK1 (Life t...More data for this Ligand-Target Pair
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Date in BDB:
2/28/2024
Entry Details
US Patent