BDBM643775 US11866405, Example 70

SMILES COc1cc2nn(cc2cc1C(=O)Nc1cnc2cccnn12)[C@@H]1CC[C@@]2(CN(C)C(=O)C2)C[C@H]1C

InChI Key InChIKey=FPKKDOBYMSIEKC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 643775   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

US Patent
LigandPNGBDBM643775(US11866405, Example 70)
Affinity DataIC50: 0.400nMAssay Description:The inhibitory activity of compounds against IRAK4 were determined in an enzymatic assay using mass spectrometry readout. Ten point half-log compound...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
US Patent