BDBM644171 6-bromo-4-(4-(2-hydroxy-4-methylbenzyl)piperazin-1-yl)-2-oxo-1-(prop-2-yn-1-yl)-1,2-dihydro-1,5-naphthyridine-3-carbonitrile::US11866430, Example 66

SMILES Cc1ccc(CN2CCN(CC2)c2c(C#N)c(=O)n(CC#C)c3ccc(Br)nc23)c(O)c1

InChI Key InChIKey=UHXDKAZKPNSWCY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 644171   

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM644171(6-bromo-4-(4-(2-hydroxy-4-methylbenzyl)piperazin-1...)
Affinity DataIC50:  1.30E+4nMAssay Description:The compound inhibition studies were carried out as follows: 50 nL droplets of each test compound (top concentration 10 mM with 11 point, 3-fold dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetDiacylglycerol kinase alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM644171(6-bromo-4-(4-(2-hydroxy-4-methylbenzyl)piperazin-1...)
Affinity DataIC50:  84nMAssay Description:The compound inhibition studies were carried out as follows: 50 nL droplets of each test compound (top concentration 10 mM with 11 point, 3-fold dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent