BDBM644460 5-(3-(4-((3-Chloro-4-(trifluoromethoxy)benzyl)amino)butoxy)azetidin-1-yl)benzo[c][2,6]naphthyridine-8-carboxylic Acid::US11866436, Example 54

SMILES OC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1ccc(OC(F)(F)F)c(Cl)c1)c1ccncc21

InChI Key InChIKey=KHQBJGWNPXLJQL-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 644460   

TargetCasein kinase II subunit alpha [2-329](Human)
Cambridge Enterprise

US Patent
LigandChemical structure of BindingDB Monomer ID 644460BDBM644460(US11866436, Example 54 | 5-(3-(4-((3-Chloro-4-(tri...)
Affinity DataIC50: 0.688nMAssay Description:Final assay conditions comprised 0.2 nM CK2α, 50 μM peptide substrate (RRRADDSDDDDD), 15 μM ATP in 1× reaction buffer (40 mM Tris pH7....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK2(Human)
Cambridge Enterprise

US Patent
LigandChemical structure of BindingDB Monomer ID 644460BDBM644460(US11866436, Example 54 | 5-(3-(4-((3-Chloro-4-(tri...)
Affinity DataIC50: 142nMAssay Description:The assay was conducted in the same way as described for CK2α, with final assay conditions comprising 20 nM CLK2 (Carna Biosciences-04-127), 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
US Patent