BDBM645368 Trans-4-((4-((2-(1-(phenylsulfonyl)) indolin-5-yl)cyclopropylamino) methyl)piperidin-1-yl)methyl) benzoic acid::US11873292, Compound A26

SMILES OC(=O)c1ccc(CN2CCC(CNC3CC3c3ccc4N(CCc4c3)S(=O)(=O)c3ccccc3)CC2)cc1

InChI Key InChIKey=JGRAADVSVNRUKB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 645368   

TargetLysine-specific histone demethylase 1A(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM645368(Trans-4-((4-((2-(1-(phenylsulfonyl)) indolin-5-yl)...)
Affinity DataIC50: 461nMAssay Description:Principle: LSD1 specifically removes the methylation modification at K4 lysine on H3 polypeptide substrate, making it a substrate without methylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2024
Entry Details
US Patent