BDBM645548 4-{[6-(5-chloro-2-fluorophen- yl)pyridazin-4-yl]amino}- quinolin-7-yl 7-methyl-2,7- diazaspiro[3.5]nonane-2- carboxylate::US20240018122, Example 115

SMILES CN1CCC2(CN(C2)C(=O)Oc2ccc3c(Nc4cnnc(c4)-c4cc(Cl)ccc4F)ccnc3c2)CC1

InChI Key InChIKey=KNBPRYIBAOMFEN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 645548   

TargetTGF-beta receptor type-1(Human)
Chiesi Farmaceutici

US Patent
LigandPNGBDBM645548(US20240018122, Example 115 | 4-{[6-(5-chloro-2-flu...)
Affinity DataIC50: 1nMAssay Description:The enzymatic activity of compounds of the present invention was monitored measuring the formation of ADP using the ADP-GLO Kinases assay. Following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Chiesi Farmaceutici

US Patent
LigandPNGBDBM645548(US20240018122, Example 115 | 4-{[6-(5-chloro-2-flu...)
Affinity DataIC50: 1nMAssay Description:The enzymatic activity of compounds of the present invention was monitored measuring the formation of ADP using the ADP-GLO Kinases assay. Following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent