BDBM645559 US20240018122, Example 165::methyl 4-{[6-(5-chloro-2- fluorophenyl)-3-(hydroxy- methyl)pyridazin-4-yl]amino}- 7-[2-(4-methylpiperazin-1-yl)- ethoxy]quinoline-6-carboxylate

SMILES COC(=O)c1cc2c(Nc3cc(nnc3CO)-c3cc(Cl)ccc3F)ccnc2cc1OCCN1CCN(C)CC1

InChI Key InChIKey=XBVIUIKHOGYTIW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 645559   

TargetTGF-beta receptor type-1(Human)
Chiesi Farmaceutici

US Patent
LigandPNGBDBM645559(US20240018122, Example 165 | methyl 4-{[6-(5-chlor...)
Affinity DataIC50: 1nMAssay Description:The enzymatic activity of compounds of the present invention was monitored measuring the formation of ADP using the ADP-GLO Kinases assay. Following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Chiesi Farmaceutici

US Patent
LigandPNGBDBM645559(US20240018122, Example 165 | methyl 4-{[6-(5-chlor...)
Affinity DataIC50: 1nMAssay Description:The enzymatic activity of compounds of the present invention was monitored measuring the formation of ADP using the ADP-GLO Kinases assay. Following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent