BDBM645560 US20240018122, Example 171::methyl 4-{[6-(5-chloro-2- fluorophenyl)pyridazin-4-yl]- amino}-7-[2-(4-methyl- piperazin-1-yl)ethoxy]- quinoline-6-carboxylate

SMILES COC(=O)c1cc2c(Nc3cnnc(c3)-c3cc(Cl)ccc3F)ccnc2cc1OCCN1CCN(C)CC1

InChI Key InChIKey=SIIVHQWYXWOMPN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 645560   

TargetTGF-beta receptor type-1(Human)
Chiesi Farmaceutici

US Patent
LigandPNGBDBM645560(US20240018122, Example 171 | methyl 4-{[6-(5-chlor...)
Affinity DataIC50: 1nMAssay Description:The enzymatic activity of compounds of the present invention was monitored measuring the formation of ADP using the ADP-GLO Kinases assay. Following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Chiesi Farmaceutici

US Patent
LigandPNGBDBM645560(US20240018122, Example 171 | methyl 4-{[6-(5-chlor...)
Affinity DataIC50: 1nMAssay Description:The enzymatic activity of compounds of the present invention was monitored measuring the formation of ADP using the ADP-GLO Kinases assay. Following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent