BDBM645562 N-[6-(5-chloro-2-fluorophenyl)- 3-(trifluoromethyl)pyridazin-4- yl]-7-[2-(4-methylpiperazin-1- yl)ethoxy]quinolin-4-amine::US20240018122, Example 183

SMILES CN1CCN(CCOc2ccc3c(Nc4cc(nnc4C(F)(F)F)-c4cc(Cl)ccc4F)ccnc3c2)CC1

InChI Key InChIKey=IPHZXCIBWYJHJC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 645562   

TargetTGF-beta receptor type-1(Human)
Chiesi Farmaceutici

US Patent
LigandPNGBDBM645562(US20240018122, Example 183 | N-[6-(5-chloro-2-fluo...)
Affinity DataIC50: 1nMAssay Description:The enzymatic activity of compounds of the present invention was monitored measuring the formation of ADP using the ADP-GLO Kinases assay. Following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Chiesi Farmaceutici

US Patent
LigandPNGBDBM645562(US20240018122, Example 183 | N-[6-(5-chloro-2-fluo...)
Affinity DataIC50: 1nMAssay Description:The enzymatic activity of compounds of the present invention was monitored measuring the formation of ADP using the ADP-GLO Kinases assay. Following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent