BDBM645822 (R)-2-chloro-N-(5-chloro-6-(4-(hydroxymethyl)-2H-1,2,3-triazol-2-yl)pyridin-3-yi)-8-methyl-8-(trifluoromethyl)-7,8-dihydro-6H-pyrazolo[1,5-a]pyrrolo[2,3-e]pyrimidine-6-carboxamide::US20240018157, Example 24

SMILES C[C@]1(CN(C(=O)Nc2cnc(c(Cl)c2)-n2ncc(CO)n2)c2cnc3cc(Cl)nn3c12)C(F)(F)F

InChI Key InChIKey=HQOXWJZPIWNCRS-GOSISDBHSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 645822   

LigandPNGBDBM645822((R)-2-chloro-N-(5-chloro-6-(4-(hydroxymethyl)-2H-1...)
Affinity DataIC50: <10nMAssay Description:The final assay buffer includes 1 nM of MALT1 full-length protein, 50 μM Ac-LRSR-AMC substrate, 50 mM Tris pH 7.5, 600 mM Sodium Citrate, 1 mM D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM645822((R)-2-chloro-N-(5-chloro-6-(4-(hydroxymethyl)-2H-1...)
Affinity DataIC50: <10nMAssay Description:The final assay buffer includes 2 nM of MALT1 full-length protein, 50 μM Ac-LRSR-AMC substrate, 50 mM Tris pH 7.5, 600 mM Sodium Citrate, 1 mM D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent