BDBM646454 US11878973, Example 48

SMILES CCc1c(N2CCN(CC2)C(=O)c2nccc(F)c2O)c(=O)n2nc(nc2n1CC(=O)Nc1ccc(nc1Cl)C(F)(F)F)C1=CCOCC1

InChI Key InChIKey=YDVBLMVAYANEMT-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 646454   

TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Human)
Novartis

US Patent

LigandBDBM646454(US11878973, Example 48)Copy SMILESCopy InChI

Affinity DataIC50:  70nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

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