BDBM646606 6-bromo-N-[5-(2,2- difluoroethyl)-4,6-dimethoxy- pyrimidin-2-yl]-1H- pyrrolo[2,3-b]pyridine-3- sulfonamide::US20240025883, Example 111::US20240025883, Example 288

SMILES COc1nc(NS(=O)(=O)c2c[nH]c3nc(Br)ccc23)nc(OC)c1CC(F)CF

InChI Key InChIKey=NEPMGCNLVAPUQJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 646606   

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM646606(US20240025883, Example 288 | 6-bromo-N-[5-(2,2- di...)
Affinity DataIC50: 13nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM646606(US20240025883, Example 288 | 6-bromo-N-[5-(2,2- di...)
Affinity DataIC50: 57nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent