BDBM647617 (R)-4-(6-(1H-pyrazol-3-yl)-1-((trifluoromethyl)sulfonyl)-1,2,3,6-tetrahydropyrazolo[3,4-b]pyrrolo[2,3-d]pyridin-4-yl)-3-methylmorpholine trifluoroacetate ::US20240025899, Compound 6

SMILES C[C@@H]1COCCN1c1nc2n(ncc2c2N(CCc12)S(=O)(=O)C(F)(F)F)-c1cc[nH]n1

InChI Key InChIKey=IXTTWEOBPPQYOM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 647617   

TargetSerine/threonine-protein kinase ATR [14-953](Human)
Shanghai De Novo Pharmatech

US Patent
LigandPNGBDBM647617(US20240025899, Compound 6 | (R)-4-(6-(1H-pyrazol-3...)
Affinity DataIC50: 4.80nMAssay Description:In this experiment, the phosphorylation level of substrate protein P53 (Eurofins, 14-952) was detected by HTRF technology to measure the activity of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent