BDBM647622 (R)-4-(6-(1H-pyrazol-3-yl)-1-(pyridin-3-yl)-1,2,3,6-tetrahydropyrazolo[3,4-b]pyrrolo[2,3-d]pyridin-4-yl)-3-methylmorpholine trifluoroacetate ::US20240025899, Compound 13

SMILES C[C@@H]1COCCN1c1nc2n(ncc2c2N(CCc12)c1cccnc1)-c1cc[nH]n1

InChI Key InChIKey=PUSBIKQHAMGMCA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 647622   

TargetSerine/threonine-protein kinase ATR [14-953](Human)
Shanghai De Novo Pharmatech

US Patent
LigandPNGBDBM647622(US20240025899, Compound 13 | (R)-4-(6-(1H-pyrazol-...)
Affinity DataIC50: 7.5nMAssay Description:In this experiment, the phosphorylation level of substrate protein P53 (Eurofins, 14-952) was detected by HTRF technology to measure the activity of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent