BDBM647699 (5S)-5-(3,5-difluorophenyl)-2-(4- fluoropentacy- clo[4.2.0.0~2,5~.0~3,8~.0~4,7~] octan-1-yl)-2,5,6,7-tetrahydro- 3H-pyrrolo[2,1-c][1,2,4]triazol-3-one::US20240025912, Compound 1-20

SMILES Fc1cc(F)cc(c1)[C@@H]1CCc2nn(c(=O)n12)C12C3C4C1C1C2C3C41F

InChI Key InChIKey=ZKPYJNDMMAQJEX-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 647699   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM647699(US20240025912, Compound 1-20 | (5S)-5-(3,5-difluor...)
Affinity DataEC50:  38.5nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent