BDBM647740 (5S,7S)-7-fluoro-2-(3- fluorobicyclo[1.1.1]pentan-1-yl)-5- (pyrazin-2-yl)-2,5,6,7-tetrahydro-3H- pyrrolo[2,1-c][1,2,4]triazol-3-one::US20240025912, Compound 4-17

SMILES F[C@H]1C[C@@H](c2cnccn2)n2c1nn(c2=O)C12CC(F)(C1)C2

InChI Key InChIKey=MNHLRPOOHGPJJC-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 647740   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM647740(US20240025912, Compound 4-17 | (5S,7S)-7-fluoro-2-...)
Affinity DataEC50:  38.8nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
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Date in BDB:
3/19/2024
Entry Details
US Patent