BDBM647746 (5S)-5-(3,5-difluorophenyl)-7-(S or R)- fluoro-2-(3-fluorobicyclo[1.1.1]pentan- 1-yl)-2,5,6,7-tetrahydro-3H- pyrrolo[2,1-c][1,2,4]triazol-3-one::US20240025912, Compound 6-1::US20240025912, Compound 6-2

SMILES FC1C[C@@H](c2cc(F)cc(F)c2)n2c1nn(c2=O)C12CC(F)(C1)C2

InChI Key InChIKey=YXHMGPXGHTVYCL-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 647746   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM647746((5S)-5-(3,5-difluorophenyl)-7-(S or R)- fluoro-2-(...)
Affinity DataEC50:  18.4nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM647746((5S)-5-(3,5-difluorophenyl)-7-(S or R)- fluoro-2-(...)
Affinity DataEC50:  116nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent