BDBM647754 3-[(5S)-5-(3,5-difluorophenyl)-7-(S or R)-fluoro-3-oxo-6,7-dihydro-3H- pyrrolo[2,1-c][1,2,4]triazol-2(5H)- yl]bicyclo[1.1.1]pentane-1-carbonitrile::US20240025912, Compound 6-5::US20240025912, Compound 6-6

SMILES FC1C[C@@H](c2cc(F)cc(F)c2)n2c1nn(c2=O)C12CC(C1)(C2)C#N

InChI Key InChIKey=JYLCEJSNBRYKBF-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 647754   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM647754(3-[(5S)-5-(3,5-difluorophenyl)-7-(S or R)-fluoro-3...)
Affinity DataEC50:  20.5nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM647754(3-[(5S)-5-(3,5-difluorophenyl)-7-(S or R)-fluoro-3...)
Affinity DataEC50:  274nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent