BDBM647762 3-[(5S)-7-(S or R)-fluoro-5-(2- fluorophenyl)-3-oxo-6,7-dihydro-3H- pyrrolo[2,1-c][1,2,4]triazol-2(5H)- yl]bicyclo[1.1.1]pentane-1-carbonitrile::US20240025912, Compound 6-10::US20240025912, Compound 6-9

SMILES FC1C[C@@H](c2ccccc2F)n2c1nn(c2=O)C12CC(C1)(C2)C#N

InChI Key InChIKey=CACYAMQPVWSSMY-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 647762   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM647762(US20240025912, Compound 6-10 | 3-[(5S)-7-(S or R)-...)
Affinity DataEC50:  18.1nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM647762(US20240025912, Compound 6-10 | 3-[(5S)-7-(S or R)-...)
Affinity DataEC50:  68.9nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent