BDBM647771 (S)-5-(3,5-difluorophenyl)-2-(3- fluorobicyclo[1.1.1]pentan-1-yl)- 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3- a]pyridin-3(2H)-one::US20240025912, Compound 1-58

SMILES Fc1cc(F)cc(c1)[C@@H]1CCCc2nn(c(=O)n12)C12CC(F)(C1)C2

InChI Key InChIKey=BVPXCXUFRMGNSC-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 647771   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM647771(US20240025912, Compound 1-58 | (S)-5-(3,5-difluoro...)
Affinity DataEC50:  45.9nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent