BDBM648221 5-({6-Amino-2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-3-methyl-hexanoyl}amino)pyrazolo[1,5-a]pyridine-3-carboxamidetrifluoroacetate (Racemic Mixture of Diastereomers)::US11884660, Example 1

SMILES COc1cn(C(C(C)CCCN)C(=O)Nc2ccn3ncc(C(N)=O)c3c2)c(=O)cc1-c1cc(Cl)ccc1C#N

InChI Key InChIKey=DMZIQKQZJWOEOD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 648221   

TargetPlasma kallikrein(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM648221(US11884660, Example 1 | 5-({6-Amino-2-[4-(5-chloro...)
Affinity DataIC50: 5.60nMAssay Description:Table A: Test substances are dissolved in dimethyl sulphoxide and serially diluted in dimethyl sulphoxide (3000 μM to 0.0078 μM; resulting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM648221(US11884660, Example 1 | 5-({6-Amino-2-[4-(5-chloro...)
Affinity DataIC50: 1.00E+4nMAssay Description:Table B: Test substances are dissolved in dimethyl sulphoxide and serially diluted in dimethyl sulphoxide (3000 μM to 0.0078 μM; resulting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
US Patent