BDBM648222 5-({(2S)-6-Amino-2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-3-methylhexanoyl}amino)pyrazolo[1,5-a]pyridine-3-carboxamide trifluoroacetate (Stereoisomer 3)::US11884660, Example 2::US11884660, Example 3

SMILES COc1cn([C@@H](C(C)CCCN)C(=O)Nc2ccn3ncc(C(N)=O)c3c2)c(=O)cc1-c1cc(Cl)ccc1C#N

InChI Key InChIKey=DMZIQKQZJWOEOD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 648222   

TargetPlasma kallikrein(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM648222(5-({(2S)-6-Amino-2-[4-(5-chloro-2-cyanophenyl)-5-m...)
Affinity DataIC50: 1.80nMAssay Description:Table A: Test substances are dissolved in dimethyl sulphoxide and serially diluted in dimethyl sulphoxide (3000 μM to 0.0078 μM; resulting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM648222(5-({(2S)-6-Amino-2-[4-(5-chloro-2-cyanophenyl)-5-m...)
Affinity DataIC50: 2.10nMAssay Description:Table A: Test substances are dissolved in dimethyl sulphoxide and serially diluted in dimethyl sulphoxide (3000 μM to 0.0078 μM; resulting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM648222(5-({(2S)-6-Amino-2-[4-(5-chloro-2-cyanophenyl)-5-m...)
Affinity DataIC50: 2.00E+3nMAssay Description:Table B: Test substances are dissolved in dimethyl sulphoxide and serially diluted in dimethyl sulphoxide (3000 μM to 0.0078 μM; resulting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM648222(5-({(2S)-6-Amino-2-[4-(5-chloro-2-cyanophenyl)-5-m...)
Affinity DataIC50: 2.00E+3nMAssay Description:Table B: Test substances are dissolved in dimethyl sulphoxide and serially diluted in dimethyl sulphoxide (3000 μM to 0.0078 μM; resulting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
US Patent