BDBM648890 6-methyl-8-(8-methyl-5-oxa-8-azaspiro[3.5]nonan- 2-yl)-N-(1-(methylsulfonyl)piperidin-4- yl)pyrido[3,4-d]pyrimidin-2-amine::US20240034731, Compound 84

SMILES CN1CCOC2(CN(C2)c2nc(C)cc3cnc(NC4CCN(CC4)S(C)(=O)=O)nc23)C1

InChI Key InChIKey=GTSLSAMSMJXMRA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 648890   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648890(6-methyl-8-(8-methyl-5-oxa-8-azaspiro[3.5]nonan- 2...)
Affinity DataIC50: 200nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648890(6-methyl-8-(8-methyl-5-oxa-8-azaspiro[3.5]nonan- 2...)
Affinity DataIC50: 200nMAssay Description:The purpose of CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Chelation-En...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 4/6(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648890(6-methyl-8-(8-methyl-5-oxa-8-azaspiro[3.5]nonan- 2...)
Affinity DataIC50: 200nMAssay Description:The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition and IC50 values) in the presence of small molecule inhibitors by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648890(6-methyl-8-(8-methyl-5-oxa-8-azaspiro[3.5]nonan- 2...)
Affinity DataIC50: 375nMAssay Description:The purpose of CDK1/Cyclin B1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent