BDBM648894 1-cyclopropyl-3-(6-methyl-2-((1- (methylsulfonyl)piperidin-4-yl)amino)pyrido[3,4- d]pyrimidin-8-yl)cyclobutan-1-ol::US20240034731, Compound 88

SMILES Cc1cc2cnc(NC3CCN(CC3)S(C)(=O)=O)nc2c(n1)C1CC(O)(C1)C1CC1

InChI Key InChIKey=FXKOFVHHQFVGJZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 648894   

LigandPNGBDBM648894(1-cyclopropyl-3-(6-methyl-2-((1- (methylsulfonyl)p...)
Affinity DataIC50: 200nMAssay Description:The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition and IC50 values) in the presence of small molecule inhibitors by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM648894(1-cyclopropyl-3-(6-methyl-2-((1- (methylsulfonyl)p...)
Affinity DataIC50: 200nMAssay Description:The purpose of CDK2/Cyclin El assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM648894(1-cyclopropyl-3-(6-methyl-2-((1- (methylsulfonyl)p...)
Affinity DataIC50: 200nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648894(1-cyclopropyl-3-(6-methyl-2-((1- (methylsulfonyl)p...)
Affinity DataIC50: 200nMAssay Description:The purpose of CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Chelation-En...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 4/6(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648894(1-cyclopropyl-3-(6-methyl-2-((1- (methylsulfonyl)p...)
Affinity DataIC50: 200nMAssay Description:The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition and IC50 values) in the presence of small molecule inhibitors by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent

LigandPNGBDBM648894(1-cyclopropyl-3-(6-methyl-2-((1- (methylsulfonyl)p...)
Affinity DataIC50: 350nMAssay Description:The purpose of CDK1/Cyclin Bi assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648894(1-cyclopropyl-3-(6-methyl-2-((1- (methylsulfonyl)p...)
Affinity DataIC50: 375nMAssay Description:The purpose of CDK1/Cyclin B1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent