BDBM649517 (S)-(2,7-Dimethyl-3-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)- 2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(8- methoxyquinolin-5-yl)methanone::US11891387, Example 14

SMILES COc1ccc(C(=O)N2CCc3c(nn(C)c3-c3cc(nn3C)C(F)(F)F)[C@@H]2C)c2cccnc12

InChI Key InChIKey=DWHCUHVELQQILK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 649517   

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM649517((S)-(2,7-Dimethyl-3-(1-methyl-3-(trifluoromethyl)-...)
Affinity DataIC50: 15nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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Date in BDB:
4/8/2024
Entry Details
US Patent