BDBM649553 (S)-(2,7-Dimethyl-3-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)- 2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(3-methyl-5-(2H- 1,2,3-triazol-2-yl)phenyl)methanone::US11891387, Example 50

SMILES C[C@@H]1N(CCc2c1nn(C)c2-c1cc(n(C)n1)C(F)(F)F)C(=O)c1cc(C)cc(c1)-n1nccn1

InChI Key InChIKey=HNCHBAXQKXUNAY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 649553   

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM649553((S)-(2,7-Dimethyl-3-(1-methyl-5-(trifluoromethyl)-...)
Affinity DataIC50: 23nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
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Date in BDB:
4/8/2024
Entry Details
US Patent