BDBM649663 US20240042050, Example PhBz-10::US20240042050, Example PhBz-9

SMILES CCCNC(=O)C1=Cc2ccc(cc2N=C(N)C1)-c1cccc(c1)S(=O)(=O)N1CC(CNC(=O)OC(C)(C)C)C1

InChI Key InChIKey=ITVKOADGYXSWCL-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 649663   

TargetToll-like receptor 8(Human)
Bolt Biotherapeutics

US Patent
LigandPNGBDBM649663(US20240042050, Example PhBz-9 | US20240042050, Exa...)
Affinity DataEC50:  374nMAssay Description:HEK293 reporter cells expressing human TLR7 or human TLR8 were purchased from Invivogen and vendor protocols were followed for cellular propagation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
US Patent

TargetToll-like receptor 8(Human)
Bolt Biotherapeutics

US Patent
LigandPNGBDBM649663(US20240042050, Example PhBz-9 | US20240042050, Exa...)
Affinity DataEC50:  1.08E+3nMAssay Description:HEK293 reporter cells expressing human TLR7 or human TLR8 were purchased from Invivogen and vendor protocols were followed for cellular propagation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Bolt Biotherapeutics

US Patent
LigandPNGBDBM649663(US20240042050, Example PhBz-9 | US20240042050, Exa...)
Affinity DataEC50:  5.14E+3nMAssay Description:HEK293 reporter cells expressing human TLR7 or human TLR8 were purchased from Invivogen and vendor protocols were followed for cellular propagation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Bolt Biotherapeutics

US Patent
LigandPNGBDBM649663(US20240042050, Example PhBz-9 | US20240042050, Exa...)
Affinity DataEC50:  7.15E+3nMAssay Description:HEK293 reporter cells expressing human TLR7 or human TLR8 were purchased from Invivogen and vendor protocols were followed for cellular propagation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
US Patent