BDBM649671 (4-((3′-(3-(4-(((1-carboxy-2-hydroxyethyl)amino)methyl)-1H-1,2,3-triazol-1-yl)propanoxy)-2,2′-dimethyl-[1,1′-biphenyl]-3-yl)methoxy)-5-chloro-2-((5-cyanopyridin-3-)methoxy)benzyl)serine::US20240043392, Compound II-1

SMILES Cc1c(COc2cc(OCc3cncc(c3)C#N)c(CN[C@@H](CO)C(O)=O)cc2Cl)cccc1-c1cccc(OCCCn2cc(CNC(CO)C(O)=O)nn2)c1C

InChI Key InChIKey=VTPNBJSRZPADEN-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 649671   

TargetProgrammed cell death 1 ligand/protein 1(Human)
Xi'An Xinton Pharmaceutcal Research

US Patent
LigandPNGBDBM649671((4-((3′-(3-(4-(((1-carboxy-2-hydroxyethyl)am...)
Affinity DataIC50: 5nMAssay Description:A negative control, a positive control and drug administration groups were set up, with two duplicate wells in each group. For the positive control g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
US Patent

TargetProgrammed cell death 1 ligand 1(Human)
Xi'An Xinton Pharmaceutcal Research

US Patent
LigandPNGBDBM649671((4-((3′-(3-(4-(((1-carboxy-2-hydroxyethyl)am...)
Affinity DataKd:  50nMAssay Description:The test compound was dissolved in DMSO to make a stock solution with a final concentration of 10 mM, then diluted to 1× with 1.05× PBS-P+, and then ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
US Patent