BDBM649690 (5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3′-(3-(4-((((R)-1-ethoxy-3-hydroxy-1-oxo propan-2-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)propoxy)-2,2′-dimethyl-[1,1′-biphenyl]-3-yl)methoxy) benzyl)-D-serine::US20240043392, Compound II-18

SMILES CCOC(=O)[C@@H](CO)NCc1cn(CCCOc2cccc(c2C)-c2cccc(COc3cc(OCc4cncc(c4)C#N)c(CN[C@H](CO)C(O)=O)cc3Cl)c2C)nn1

InChI Key InChIKey=KGZGJLNMBOFLDS-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 649690   

TargetProgrammed cell death 1 ligand/protein 1(Human)
Xi'An Xinton Pharmaceutcal Research

US Patent
LigandPNGBDBM649690((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3&#...)
Affinity DataIC50: 55nMAssay Description:A negative control, a positive control and drug administration groups were set up, with two duplicate wells in each group. For the positive control g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
US Patent

TargetProgrammed cell death 1 ligand 1(Human)
Xi'An Xinton Pharmaceutcal Research

US Patent
LigandPNGBDBM649690((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3&#...)
Affinity DataKd:  550nMAssay Description:The test compound was dissolved in DMSO to make a stock solution with a final concentration of 10 mM, then diluted to 1× with 1.05× PBS-P+, and then ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
US Patent