BDBM650993 US20240043448, Example 54

SMILES CC(C)c1nccc(CCC(F)(F)CO)c1-n1c(=O)nc(N2C[C@H](C)N(C(=O)OC(C)(C)C)C[C@H]2C)c2cc(F)c(-c3c(O)ccc(F)c3F)nc21

InChI Key InChIKey=CTADKCBQFGMPAP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 650993   

TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 650993BDBM650993(US20240043448, Example 54)
Affinity DataIC50: 2.40nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
US Patent