BDBM652645 N6-((2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)methyl)isoquinoline-1,6-diamine::US20240059691, Example 4259

SMILES CN1CCC(CC1)Oc1cc(CNc2ccc3c(N)nccc3c2)ccn1

InChI Key InChIKey=BAPGDFQYYPBNAG-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 652645   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652645(N6-((2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)m...)
Affinity DataIC50:  650nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652645(N6-((2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)m...)
Affinity DataIC50:  2.50E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652645(N6-((2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)m...)
Affinity DataIC50:  2.50E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine protease 1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652645(N6-((2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)m...)
Affinity DataIC50:  2.50E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetCoagulation factor XI(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652645(N6-((2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)m...)
Affinity DataIC50:  7.50E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProthrombin(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652645(N6-((2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)m...)
Affinity DataIC50:  2.00E+3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetPlasminogen(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652645(N6-((2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)m...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetCoagulation factor X(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652645(N6-((2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)m...)
Affinity DataIC50:  6.50E+3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent