BDBM652731 (S*)-N5-((2-((2-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-7-yl)methoxy)pyridin-4- yl)methyl)isoquinoline-1,5-diamine::US20240059691, Example 4446

SMILES Cc1cn2CC[C@H](COc3cc(CNc4cccc5c(N)nccc45)ccn3)Cc2n1

InChI Key InChIKey=PGGPSANDIMXVMM-SFHVURJKSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 652731   

TargetCoagulation factor XII(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652731((S*)-N5-((2-((2-methyl-5,6,7,8-tetrahydroimidazo[1...)
Affinity DataIC50:  55nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652731((S*)-N5-((2-((2-methyl-5,6,7,8-tetrahydroimidazo[1...)
Affinity DataIC50:  6.50E+3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKallikrein-1(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652731((S*)-N5-((2-((2-methyl-5,6,7,8-tetrahydroimidazo[1...)
Affinity DataIC50:  6.50E+3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease 1(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652731((S*)-N5-((2-((2-methyl-5,6,7,8-tetrahydroimidazo[1...)
Affinity DataIC50:  2.50E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652731((S*)-N5-((2-((2-methyl-5,6,7,8-tetrahydroimidazo[1...)
Affinity DataIC50:  2.50E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652731((S*)-N5-((2-((2-methyl-5,6,7,8-tetrahydroimidazo[1...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasminogen(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652731((S*)-N5-((2-((2-methyl-5,6,7,8-tetrahydroimidazo[1...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652731((S*)-N5-((2-((2-methyl-5,6,7,8-tetrahydroimidazo[1...)
Affinity DataIC50:  6.50E+3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent