BDBM652870 1-(6-(4-(2-amino-1,3- benzothiazol-4-yl)- 5,6,7,8-tetrahydro-2- quinazolinyl)-2,6- diazaspiro[3,4]octan-2- yl)-2-propen-1-one::US20240059703, Example 1-23

SMILES Nc1nc2c(cccc2s1)-c1nc(nc2CCCCc12)N1CCC2(CN(C2)C(=O)C=C)C1

InChI Key InChIKey=NYOIIAIZDCICGW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652870   

TargetGTPase KRas(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 652870BDBM652870(US20240059703, Example 1-23 | 1-(6-(4-(2-amino-1,3...)
Affinity DataIC50: 890nMAssay Description:Inhibition of recombinant His-tagged GDP-bound human KRAS G12C/C118A mutant (1 to 169 residues) (unknown origin) extracted by Escherichia coli assess...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 652870BDBM652870(US20240059703, Example 1-23 | 1-(6-(4-(2-amino-1,3...)
Affinity DataIC50: 1.22E+3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent