BDBM652893 3-(3-(difluoromethoxy)phenyl)-1- (3-hydroxybutan-2-yl)-N-(3- methyl-1,1-dioxidothietan-3-yl)- 1H-pyrazolo[4,3-b]pyridine-6- carboxamide (2nd faster eluting in AD-H column, 15% EtOH/CO2)::US20240059700, Example 78b

SMILES CC(O)[C@H](C)n1nc(-c2cccc(OC(F)F)c2)c2ncc(cc12)C(=O)NC1(C)CS(=O)(=O)C1

InChI Key InChIKey=CXULZOUYRAHNDX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652893   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM652893(3-(3-(difluoromethoxy)phenyl)-1- (3-hydroxybutan-2...)
Affinity DataIC50: 4.40nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent