BDBM652904 1-(3-cyano-3-methylcyclobutyl)- 3-(3-(difluoromethoxy)phenyl)- N-(3-methyl-1,1-dioxidothietan- 3-yl)-1H-pyrazolo[4,3- b]pyridine-6-carboxamide (diastereomer I)::US20240059700, Example 87a

SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cnc2c(nn(C3C[C@](C)(C3)C#N)c2c1)-c1cccc(OC(F)F)c1

InChI Key InChIKey=VVCLGBYDBGNGHK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652904   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM652904(1-(3-cyano-3-methylcyclobutyl)- 3-(3-(difluorometh...)
Affinity DataIC50: 70nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent