BDBM652943 1-(6-(4-(6- chloro-5-methyl- 1H-indazol-4- yl)-3,7,7- trimethyl-7,8- dihydro-5H- pyrano[4,3- b]pyridin-2-yl)- 2,6- diazaspiro[3.4] octan-2-yl)-2- propen-1-one::US20240059703, Example 2-36

SMILES C=CC(=O)N1CC2(CCN(c3nc4c(c(-c5c(C)c(Cl)cc6[nH]ncc56)c3C)COC(C)(C)C4)C2)C1

InChI Key InChIKey=ZNODACHBSBXRCQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652943   

LigandChemical structure of BindingDB Monomer ID 652943BDBM652943(US20240059703, Example 2-36 | 1-(6-(4-(6- chloro-5...)
Affinity DataIC50: 20nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent