BDBM652960 8-(3-hydroxy-1- naphthalenyl)-6- (2-(2- propenoyl)-2,6- diazaspiro[3.4] octan-6-yl)-3,4- dihydro-2H- chromene-7- carbonitrile::US20240059703, Example 2-52::US20240059703, Example 2-53::US20240059703, Example 2-54

SMILES C=CC(=O)N1CC2(CCN(c3cc4c(c(-c5cc(O)cc6ccccc56)c3C#N)OCCC4)C2)C1

InChI Key InChIKey=QNWYXDNBFLMCHT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 652960   

LigandChemical structure of BindingDB Monomer ID 652960BDBM652960(US20240059703, Example 2-54 | 8-(3-hydroxy-1- naph...)
Affinity DataIC50: 26nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 652960BDBM652960(US20240059703, Example 2-54 | 8-(3-hydroxy-1- naph...)
Affinity DataIC50: 28nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 652960BDBM652960(US20240059703, Example 2-54 | 8-(3-hydroxy-1- naph...)
Affinity DataIC50: 7.11E+3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent