BDBM652984 1-(6-(3-chloro- 4-(3-hydroxy-1- naphthalenyl)- 7,7-dimethyl- 7,8-dihydro-5H- pyrano[4,3- b]pyridin-2-yl)- 2,6- diazaspiro[3.4] octan-2-yl)-2- propen-1-one::US20240059703, Example 2-76::US20240059703, Example 2-77::US20240059703, Example 2-78

SMILES CC1(C)Cc2nc(N3CCC4(CN(C4)C(=O)C=C)C3)c(Cl)c(c2CO1)-c1cc(O)cc2ccccc12

InChI Key InChIKey=XHYARIZOASKQCG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 652984   

LigandPNGBDBM652984(US20240059703, Example 2-76 | US20240059703, Examp...)
Affinity DataIC50: 18nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM652984(US20240059703, Example 2-76 | US20240059703, Examp...)
Affinity DataIC50: 31nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM652984(US20240059703, Example 2-76 | US20240059703, Examp...)
Affinity DataIC50: 3.90E+3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent