BDBM653000 1-(6-(3-chloro- 4-(6-chloro-5- methyl-1H- indazol-4-yl)- 7,7-dimethyl- 7,8-dihydro-5H- pyrano[4,3- b]pyridin-2-yl)- 2,6- diazaspiro[3.4] octan-2-yl)-2- propen-1-one::US20240059703, Example 2-108::US20240059703, Example 2-109::US20240059703, Example 2-92

SMILES Cc1c(Cl)cc2[nH]ncc2c1-c1c(Cl)c(nc2CC(C)(C)OCc12)N1CCC2(CN(C2)C(=O)C=C)C1

InChI Key InChIKey=RDFNLXNBGDCBLV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 653000   

LigandPNGBDBM653000(US20240059703, Example 2-108 | US20240059703, Exam...)
Affinity DataIC50: 21nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM653000(US20240059703, Example 2-108 | US20240059703, Exam...)
Affinity DataIC50: 23nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM653000(US20240059703, Example 2-108 | US20240059703, Exam...)
Affinity DataIC50: 1.41E+4nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent