BDBM653001 1-(5-methyl-1H- indazol-4-yl)-3- (2-(2- propenoyl)-2,6- diazaspiro[3.4] octan-6-yl)- 5,6,7,8- tetrahydro-2- naphthalene- carbonitrile::US20240059703, Example 2-93

SMILES C=CC(=O)N1CC2(CCN(c3cc4c(c(-c5c(C)ccc6[nH]ncc56)c3C#N)CCCC4)C2)C1

InChI Key InChIKey=VBXFHIAJIJRGGG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 653001   

LigandChemical structure of BindingDB Monomer ID 653001BDBM653001(US20240059703, Example 2-93 | 1-(5-methyl-1H- inda...)
Affinity DataIC50: 19nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
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Date in BDB:
4/24/2024
Entry Details
US Patent