BDBM653012 8-(5-chloro-1,6- dimethyl-1H- indazol-7-yl)-6- (2-(2- propenoyl)-2,6- diazaspiro[3.4] octan-6-yl)-3,4- dihydro-2H- chromene-7- carbonitrile::US20240059703, Example 2-104

SMILES C=CC(=O)N1CC2(CCN(c3cc4c(c(-c5c(C)c(Cl)cc6cnn(C)c56)c3C#N)OCCC4)C2)C1

InChI Key InChIKey=SDRIOXZLDQIJKX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 653012   

LigandChemical structure of BindingDB Monomer ID 653012BDBM653012(US20240059703, Example 2-104 | 8-(5-chloro-1,6- di...)
Affinity DataIC50: 18nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
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Date in BDB:
4/24/2024
Entry Details
US Patent