BDBM653061 (1R,9R)-6-(2-chloro-3- fluoro-5- hydroxyphenyl)-10,10- dimethyl-4-(2-(2- propenoyl)-2,6- diazaspiro[3.4]octan-6- yl)-3- azatricyclo[7.1.1.02,7] undeca-2,4,6-triene-5- carbonitrile::US20240059703, Example 12-34
SMILES CC1(C)[C@@H]2C[C@H]1c1nc(N3CCC4(CN(C4)C(=O)C=C)C3)c(C#N)c(c1C2)-c1cc(O)cc(F)c1Cl
InChI Key InChIKey=AYCVIMRCBOCBRM-YWZLYKJASA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 653061
TargetGTPase KRas [1-169,G12C,C118A]/Son of sevenless homolog 1 [564-1049](Homo sapiens (Human))
Amgen
US Patent
Amgen
US Patent
Affinity DataIC50: 20nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair