BDBM653126 (P)-6,6-dimethyl-4-(5- methyl-1H-indazol-4-yl)-2- ((5R)-5-methyl-2-(2- propenoyl)-2,6- diazaspiro[3.4]octan-6-yl)- 6,7-dihydro-5H- cyclopenta[b]pyridine-3- carbonitrile (4th eluting peak)::US20240059703, Example 13-54

SMILES C=CC(=O)N1CC2(CCN(c3nc4c(c(-c5c(C)ccc6[nH]ncc56)c3C#N)CC(C)(C)C4)[C@@H]2C)C1

InChI Key InChIKey=JSLODKGWNNCFDO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 653126   

LigandChemical structure of BindingDB Monomer ID 653126BDBM653126(US20240059703, Example 13-54 | (P)-6,6-dimethyl-4-...)
Affinity DataIC50: 17nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
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Date in BDB:
4/24/2024
Entry Details
US Patent