BDBM653137 4-(3-hydroxy-1- naphthalenyl)-6,6-dimethyl- 2-(2-(2-propenoyl)-2,6- diazaspiro[3.4]octan-6-yl)- 6,7-dihydro-5H- cyclopenta[b]pyridine-3- carbonitirle::US20240059703, Example 13-65::US20240059703, Example 13-68::US20240059703, Example 13-69

SMILES C=CC(=O)N1CC2(CCN(c3nc4c(c(-c5cc(O)cc6ccccc56)c3C#N)CC(C)(C)C4)C2)C1

InChI Key InChIKey=RRGVWQMBOPJEAI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 653137   

LigandChemical structure of BindingDB Monomer ID 653137BDBM653137(US20240059703, Example 13-65 | 4-(3-hydroxy-1- nap...)
Affinity DataIC50: 27nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 653137BDBM653137(US20240059703, Example 13-65 | 4-(3-hydroxy-1- nap...)
Affinity DataIC50: 74nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 653137BDBM653137(US20240059703, Example 13-65 | 4-(3-hydroxy-1- nap...)
Affinity DataIC50: 2.70E+4nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent