BDBM653162 7,7-dimethyl-2-(2-(2- propenoyl)-2,6- diazaspiro[3.4]octan-6-yl)- 4-(1,5,6-trimethyl-1H- indazol-7-yl)-7,8-dihydro- 5H-pyrano[4,3-b]pyridine- 3-carbonitrile::US20240059703, Example 13-90::US20240059703, Example 13-91::US20240059703, Example 13-92

SMILES C=CC(=O)N1CC2(CCN(c3nc4c(c(-c5c(C)c(C)cc6cnn(C)c56)c3C#N)COC(C)(C)C4)C2)C1

InChI Key InChIKey=ZXHKWBGKLYUDTQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 653162   

LigandChemical structure of BindingDB Monomer ID 653162BDBM653162(US20240059703, Example 13-91 | US20240059703, Exam...)
Affinity DataIC50: 13nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 653162BDBM653162(US20240059703, Example 13-91 | US20240059703, Exam...)
Affinity DataIC50: 27nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 653162BDBM653162(US20240059703, Example 13-91 | US20240059703, Exam...)
Affinity DataIC50: 9.27E+3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent