BDBM653244 (1S,8R)-6-(1,6-dimethyl- 1H-indazol-7-yl)-4-(2- (2-propenoyl)-2,6- diazaspiro[3.4]octan-6- yl)-3- azatricyclo[6.2.1.02,7] undeca-2,4,6-triene-5- carbonitrile::US20240059703, Example 14-15::US20240059703, Example 14-16::US20240059703, Example 14-17

SMILES Cc1ccc2cnn(C)c2c1-c1c2[C@@H]3CC[C@@H](C3)c2nc(N2CCC3(CN(C3)C(=O)C=C)C2)c1C#N

InChI Key InChIKey=MMVMTMRRANLFRM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 653244   

LigandPNGBDBM653244(US20240059703, Example 14-15 | (1S,8R)-6-(1,6-dime...)
Affinity DataIC50: 22nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM653244(US20240059703, Example 14-15 | (1S,8R)-6-(1,6-dime...)
Affinity DataIC50: 49nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM653244(US20240059703, Example 14-15 | (1S,8R)-6-(1,6-dime...)
Affinity DataIC50: 2.50E+5nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent